HCID 23003649, compound → HCID 23003688, compound

HRID 657177Notes

Reaction equation

HRID 657177 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5](CC2C=CC=CC=2)[CH2:4][CH:3]1[CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20]>CO.[OH-].[OH-].[Pd+2]>[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH:3]1[CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22]

Participants

4

Reactant 1

HCID 23003649HCID 23003649, compound

Product 1

HCID 23003688HCID 23003688, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A solution of 1,1-dimethylethyl {[4-hydroxy-1-(phenylmethyl)-3-piperidinyl]methyl}carbamate (3.7 g, 11.56 mmol) in methanol (70 ml) was stirred under hydrogen at room temperature with 20% palladium hydroxide/carbon (moist, 0.7 g) overnight. After filtration through kieselguhr, the methanol was evaporated to afford the desired product (2.65 g, 100%).

Workup

  1. filtrationAfter filtration through kieselguhr
  2. customthe methanol was evaporated

Sources & evidence

ORD record
ord-01d2e1246f69465389903d35c1b29a0d
Source dataset
uspto-grants-2011_12
Patent number
US08071592B2

Reaction notes

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