反应详情

3-Bromo-4-chlorobenzoic acid (2.35 g, 10 mmol) was suspended in CH2Cl2 (50 mL) and stirred under argon at room temperature. Oxalyl chloride (2.53 g, 20 mmol) was added followed by DMF (10 μL). Gas evolution began, and the mixture was stirred until gas evolution ceased. The solvents were pumped off and toluene was added and stripped off to remove excess oxalyl chloride. The residue was taken up in EtOAc and added to concentrated ammonium hydroxide (10 mL). This was stirred for 30 min. The phases were separated and the organic washed 1× with brine dried over anhydrous Na2SO4, filtered, and evaporated. The residue was crystallized from EtOAc/hexane to give the title compound as a white crystalline solid. LC-MS m/z 233.7 (M+H)+, 1.54 min (ret time); mp 146-147° C.; analytical HPLC shows 100% purity, (ret time: 11.835 min).

1. stirringthe mixture was stirred until gas evolution
2. customto remove excess oxalyl chloride
3. additionadded to concentrated ammonium hydroxide (10 mL)
4. stirringThis was stirred for 30 min
5. customThe phases were separated
6. washthe organic washed 1× with brine
7. dry with materialdried over anhydrous Na2SO4
8. filtrationfiltered
9. customevaporated
10. customThe residue was crystallized from EtOAc/hexane