Sodium Chloride → HCID 17973399, compound

HRID 657449Notes

Reaction equation

HRID 657449 reaction equation
[CH:1]1(/[CH:7]=[CH:8]/[C:9]([OH:11])=O)[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]1.ClC(OCC)=O.C(N(CC)CC)C.[CH:25]1([NH2:28])[CH2:27][CH2:26]1.[Cl-].[Na+]>>[CH:25]1([NH:28][C:9](=[O:11])/[CH:8]=[CH:7]/[CH:1]2[CH2:6][CH2:5][CH:4]=[CH:3][CH2:2]2)[CH2:27][CH2:26]1

Participants

6

Reactant 5

HCID 5234Sodium ChlorideHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 69828CyclopropylamineHCID 5364373HCID 5364373, compound

Product 1

HCID 17973399HCID 17973399, compoundYield 69%

Procedure

3-(3-Cyclohexenyl)-2E-propenoic acid 1 eq, ethyl chloroformate 1.5 eq, triethylamine 1.5 eq, cyclopropylamine 1.6 eq, quench with 10% sodium chloride solution, yield=69%.

Sources & evidence

ORD record
ord-4aed42a36dbd4166904bb68305f98850
Source dataset
uspto-grants-2011_12
Patent number
US08075937B2

Reaction notes

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