Sodium Chloride → HCID 17973402, compound

HRID 657452Notes

Reaction equation

HRID 657452 reaction equation
[C:1]1([CH2:7][CH2:8]/[CH:9]=[CH:10]/[C:11]([OH:13])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC(OCC)=O.[CH2:20]([N:22](CC)CC)[CH3:21].C(N)C.[Cl-].[Na+]>C1COCC1>[CH2:20]([NH:22][C:11](=[O:13])/[CH:10]=[CH:9]/[CH2:8][CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH3:21]

Participants

7

Reactant 5

HCID 5234Sodium ChlorideHCID 6341EthylamineHCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 5367576HCID 5367576, compound

Product 1

HCID 17973402HCID 17973402, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-Phenyl-2E-pentenoic acid 1 eq, ethyl chloroformate 1.5 eq, triethylamine 1.5 eq, ethylamine 1.5 eq as a 2.0M solution in THF, quench with 10% sodium chloride solution, yield=39%.

Sources & evidence

ORD record
ord-7ffe876026ce45868a2e1125c9790de6
Source dataset
uspto-grants-2011_12
Patent number
US08075937B2

Reaction notes

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