Hydrochloric Acid → HCID 17973396, compound

HRID 657454Notes

Reaction equation

[CH3:1]/[C:2](/[CH2:7][CH2:8][CH3:9])=[CH:3]\[C:4]([OH:6])=O.ClC(OCC)=O.C(N(CC)CC)C.[CH:23]([NH:26][CH:27]([CH3:29])[CH3:28])([CH3:25])[CH3:24].Cl>>[CH:23]([N:26]([CH:27]([CH3:29])[CH3:28])[C:4](=[O:6])/[CH:3]=[C:2](\[CH3:1])/[CH2:7][CH2:8][CH3:9])([CH3:25])[CH3:24]

Participants

Reactant 5

HCID 313Hydrochloric Acid

HCID 7912Diisopropylamine

HCID 8471Triethylamine

HCID 10928Ethyl chloroformate

HCID 6443739trans-3-Methyl-2-hexenoic acid

Product 1

HCID 17973396HCID 17973396, compoundYield 34%

Procedure

3-Methyl-2E-hexenoic acid 1 eq, ethyl chloroformate 1.5 eq, triethylamine 1.6 eq, diisopropylamine 3.0 eq, quench with 10% hydrogen chloride solution, yield=34%.

Sources & evidence

ORD record: ord-74094ba67edd4ea992605d49a9436c24
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08075937B2

Reaction notes

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