反应详情

温度

100 °C

A mixture of benzoic acid (1 g), 1,5-pentanediol (5 mL) and p-toluenesulfonic acid (110 mg) was heated in an oil-bath at 100° C. overnight. The reaction mixture was cooled to room temperature, poured into water (50 mL) and extracted with EtOAc (2×25 mL), washed with sodium carbonated (5%, 20 mL) followed by brine (15 mL). The organic layer was dried over anhyd. sodium sulfate, filtered and concentrated to give almost pure product (1.15 g, 67%);

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionextracted with EtOAc (2×25 mL)
3. washwashed with sodium
4. customThe organic layer was dried over anhyd
5. filtrationsodium sulfate, filtered
6. concentrationconcentrated