Tetrahydrofuran → 3-(7,8-Dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-[(5-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]-3-oxopropan-1-amine hydrochloride

HRID 657562Notes

Reaction equation

HRID 657562 reaction equation
[ClH:1].CO[C:4]1[CH:5]=[C:6]2[C:9](=[CH:10][C:11]=1OC)[CH:8]([CH2:14][N:15](C)[CH2:16][CH2:17][C:18]([N:20]1[CH2:26][CH2:25][C:24]3[CH:27]=C(OC)C(OC)=[CH:30][C:23]=3[CH2:22][CH2:21]1)=[O:19])[CH2:7]2.C1C[O:39][CH2:38]C1.[O:41]1[CH2:46][CH2:45][O:44][CH2:43][CH2:42]1>>[ClH:1].[CH3:43][O:44][C:45]1[C:46]([O:41][CH3:42])=[CH:30][C:23]2[CH2:22][CH2:21][N:20]([C:18](=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH:8]3[CH2:7][C:6]4[C:9]3=[C:10]([O:39][CH3:38])[CH:11]=[CH:4][CH:5]=4)[CH2:26][CH2:25][C:24]=2[CH:27]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 312751,4-DioxaneHCID 68972400N-[(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]-3-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-3-oxopropan-1amine hydrochloride

Product 1

HCID 689761333-(7,8-Dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-[(5-methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]-3-oxopropan-1-amine hydrochloride

Procedure

Obtained in the same manner as the product of Example 1, but with replacement of the [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamine in Step 4 by the product of Preparation 9 and of the THF by dioxane.

Workup

  1. customwith replacement of the [(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamine in Step 4 by the product of Preparation 9

Sources & evidence

ORD record
ord-0fc3aad22f7647feba17c7861cec7257
Source dataset
uspto-grants-2011_12
Patent number
US08076325B2

Reaction notes

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