反应详情

A mixture of methyl 4-(3-chloropropoxy)benzoate (4.57 g), potassium carbonate (8.29 g), cis and trans-3,5-dimethylpiperidine (5.31 mL) and a catalytic amount of potassium iodide in N,N-dimethylformamide (100 mL) is stirred overnight at 100° C. The suspension is filtrated and the precipitate washed with ethanol. The filtrate is concentrated under reduced pressure and purified by chromatography over silica gel with a gradient of dichloromethane/methanol from 98/2 to 90/10. Fraction containing the expected products are pooled and concentrated under reduced pressure yielding 5.33 g of cis and trans-1-{3-[4-(methoxycarbonyl)phenoxy]propyl}-3,5-dimethylpiperidine.

1. filtrationThe suspension is filtrated
2. washthe precipitate washed with ethanol
3. concentrationThe filtrate is concentrated under reduced pressure
4. custompurified by chromatography over silica gel with a gradient of dichloromethane/methanol from 98/2 to 90/10
5. additionFraction containing the expected products
6. concentrationconcentrated under reduced pressure