Aluminium lithium hydride → HCID 68905693, compound

HRID 657645Notes

Reaction equation

HRID 657645 reaction equation
[N:1]1([C:7]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][CH2:26][N:27]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]4)=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[N:1]1([CH2:7][CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[CH:19][C:20]([O:23][CH2:24][CH2:25][CH2:26][N:27]4[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]4)=[CH:21][CH:22]=3)=[CH:13][CH:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 68909667HCID 68909667, compound

Product 1

HCID 68905693HCID 68905693, compoundYield 2.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A Following the procedure of example 42§A, but starting from 1-(3-{[4′-(2-piperidinocarbonylethen-1-yl)biphenyl-4-yl]oxy}propyl)piperidine (0.6 g) and lithium aluminum hydride (120 mg) in tetrahydrofuran (15 mL) affords 15 mg of 1-(3-{[4′-(3-piperidinoprop-1-en-1-yl)biphenyl-4-yl]oxy}propyl)piperidine as pale yellow crystals melting at 100-105° C.

Sources & evidence

ORD record
ord-1683ef31f7944ae590d0745dfa350512
Source dataset
uspto-grants-2011_12
Patent number
US08076329B2

Reaction notes

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