Potassium Carbonate → HCID 23150278, compound

HRID 657656Notes

Reaction equation

HRID 657656 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[N:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>C1(C)C=CC=CC=1>[Cl:12][CH2:11][CH2:10][CH2:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([C:22]2[CH:23]=[CH:24][N:19]=[CH:20][CH:21]=2)=[CH:3][CH:4]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2734379(Pyridin-4-yl)boronic acidHCID 126856091-Bromo-4-(3-chloropropoxy)benzene

Product 1

HCID 23150278HCID 23150278, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Following the procedure described in example 24, but starting from 1-bromo-4-(3-chloropropoxy)benzene (2.5 g), potassium carbonate (4.14 g), 4-pyridylboronic acid (1.47 g) and palladium tetrakistriphenylphosphine (116 mg) in toluene (24 mL) affords 2.11 g of 4-[4-(3-chloropropoxy)phenyl]pyridine as a white solid.

Sources & evidence

ORD record
ord-51cc0671333b42e6ba8e134aff4632ae
Source dataset
uspto-grants-2011_12
Patent number
US08076329B2

Reaction notes

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