Trifluoroacetic acid → HCID 87132430, compound

HRID 657695Notes

Reaction equation

HRID 657695 reaction equation
O[C:2]([CH:6]1[CH2:9][CH:8]([CH2:10][C:11]([OH:13])=[O:12])[C:7]1([CH3:15])[CH3:14])([C:4]#[CH:5])[CH3:3].C([SiH](CC)CC)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:3]=[C:2]([CH:6]1[CH2:9][CH:8]([CH2:10][C:11]([OH:13])=[O:12])[C:7]1([CH3:15])[CH3:14])[C:4]#[CH:5]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 262808[3-(2-hydroxybut-3-yn-2-yl)-2,2-dimethylcyclobutyl]acetic acid

Product 1

HCID 87132430HCID 87132430, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of Example 29A (253 mg, 1.2 mmol) in 5 mL of CH2Cl2 was added triethylsilane (250 μL, 1.6 mmol), followed by trifluoroacetic acid (116 μL, 1.6 mmol). The resulting mixture was stirred at room temperature for overnight. Volatile organics were removed in vacuuo and the residue was evaporated with toluene (2×10 mL). The resulting title compound was used without further purification.

Workup

  1. customVolatile organics were removed in vacuuo
  2. customthe residue was evaporated with toluene (2×10 mL)
  3. customThe resulting title compound was used without further purification

Sources & evidence

ORD record
ord-683ac637dafe4ee18af3bc02174fcd82
Source dataset
uspto-grants-2011_12
Patent number
US08076344B2

Reaction notes

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