反应详情

A solution of 5-(1-azido-2-(1,3-dioxolan-2-yl)ethyl)-2-(trifluoromethyl)pyridine (7.44 g, 25.8 mmol) in tetrahydrofuran (60 mL) was treated with 20% aq. HCl (60 mL) at 0° C. The mixture was stirred at room temperature for 1.5 hours. After completion of the reaction, ethyl ether was added and the organic layer was separated, dried over MgSO4, and concentrated to yield a crude oil without further purification.

1. additionwas added
2. customthe organic layer was separated
3. dry with materialdried over MgSO4
4. concentrationconcentrated
5. customto yield a crude oil
6. customwithout further purification