反应详情

温度

40 °C

Cyclopropylmethanol (2.64 ml) was initially charged in DMF (35 ml), admixed under argon with sodium hydride (795 mg) and stirred at 40° C. for 1 h. Subsequently, 6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.001; 1.66 g), dissolved in DMF (35 ml), were added dropwise. After 1 h, the mixture was admixed with water and extracted by shaking four times with dichloromethane. The combined organic phases were dried over magnesium sulfate and concentrated by rotary evaporation. The residue was triturated with MtB ether, filtered off with suction and dried. 720 mg of the title compound were obtained.

1. additionwere added dropwise
2. waitAfter 1 h
3. extractionextracted
4. stirringby shaking four times with dichloromethane
5. dry with materialThe combined organic phases were dried over magnesium sulfate
6. concentrationconcentrated by rotary evaporation
7. customThe residue was triturated with MtB ether
8. filtrationfiltered off with suction
9. customdried