反应详情

温度

40 °C

Methyl 3-(3-acetoxy-2,2-dimethylpropoxy)-5-tert-butylbenzoate (O5.086; 1 g) was dissolved in methanol/THF (15/30 ml), and lithium hydroxide solution (11.89 ml, 1 M in water) was added. After stirring at 40° C. for 2 h, the organic solvent was drawn off, and the residue was diluted with water and adjusted to pH 3 with 1 N hydrochloric acid. Then it was extracted with EA, and the combined organic phases were dried, filtered and concentrated. 940 mg of the title compound were obtained. LC-MS rt: 1.45 min [M+H]+: 281.1 (met. a)

1. extractionThen it was extracted with EA
2. customthe combined organic phases were dried
3. filtrationfiltered
4. concentrationconcentrated