Glutaric Acid → HCID 178484388, compound

HRID 658121Notes

Reaction equation

HRID 658121 reaction equation
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:10]([OH:18])(=[O:17])[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15].C(OCC)(=O)C>CO>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:10]([O-:18])(=[O:17])[CH2:11][CH2:12][CH2:13][C:14]([O-:16])=[O:15]

Participants

5

Reactant 3

HCID 743Glutaric AcidHCID 8857Ethyl AcetateHCID 178484382HCID 178484382, compound

Product 1

HCID 178484388HCID 178484388, compoundYield 65.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10.0 g of the metformin free-base and 3.98 g of glutaric acid were stirred in 100 ml of methyl alcohol at a temperature of 40° C., and then ethyl acetate was added thereto. The produced crystal was filtered and dried in hot air, thus obtaining 5.15 g (yield: 43.8%) of metformin glutarate.

Workup

  1. filtrationThe produced crystal was filtered
  2. customdried in hot air

Sources & evidence

ORD record
ord-d99303c04d69446cad2b4281e2f52d51
Source dataset
uspto-grants-2011_12
Patent number
US08076377B2

Reaction notes

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