Potassium Carbonate → HCID 178484389, compound

HRID 658132Notes

Reaction equation

HRID 658132 reaction equation
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.C(=O)([O-])[O-].[K+].[K+].[C:17]([O-:25])(=[O:24])[CH:18]([CH2:20][C:21]([O-:23])=[O:22])[OH:19]>CN(C)C=O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:17]([O-:25])(=[O:24])[CH:18]([CH2:20][C:21]([O-:23])=[O:22])[OH:19]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 14219Metformin HydrochlorideHCID 160434DL-Malate

Product 1

HCID 178484389HCID 178484389, compoundYield 18.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

9.97 g (2 molar equivalents) of metformin hydrochloride, 8.34 g (2 molar equivalents) of potassium carbonate and 4.05 g (1 molar equivalent) of malate were stirred in N,N-dimethylformamide (DMF) at 100° C., and then the produced inorganic salt was filtered. To the filtered solution, acetone was added dropwise and stirred at room temperature. The produced crystal was filtered and dried in hot air, thus obtaining 1.49 g (yield: 12.6%) of metformin malate.

Workup

  1. filtrationthe produced inorganic salt was filtered
  2. additionTo the filtered solution, acetone was added dropwise
  3. filtrationThe produced crystal was filtered
  4. customdried in hot air

Sources & evidence

ORD record
ord-a5f3784600e8471ba83a65ca98814781
Source dataset
uspto-grants-2011_12
Patent number
US08076377B2

Reaction notes

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