反应详情

温度

0 °C

1-tert-Butoxy-3-fluoro-5-isothiocyanato-benzene (24.0 g) and triethylamine (10.9 g) are dissolved in iso-propanol (150 ml). The reaction mixture is refluxed for 18 hours and the solvent is removed by vacuo. The crude product is dissolved in hexane:diethyl ether (19:1). The diethyl ether is removed by vacuo and the solution is cooled to 0° C. for 3 hours. The solution is filtered to give the title compound. 1H nmr (CDCl3, 400 MHz); 8.10 (br s, 1H), 6.65 (br s, 2H), 6.45 (ddd, 1H) 5.60 (sept, 1H), 1.35 (d, 6H), 1.30 (s, 9H).

1. temperatureThe reaction mixture is refluxed for 18 hours
2. customthe solvent is removed by vacuo
3. dissolutionThe crude product is dissolved in hexane:diethyl ether (19:1)
4. customThe diethyl ether is removed by vacuo
5. filtrationThe solution is filtered