N-(2-Aminoethyl)piperidine → HCID 59987498, compound

HRID 658504Notes

Reaction equation

HRID 658504 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]([NH:14][C:15]3[CH:16]=[C:17]([CH:36]=[CH:37][CH:38]=3)[O:18][C:19]3[CH:24]=[CH:23][N:22]=[C:21]([C:25]([NH:27][CH2:28][CH2:29][N:30]4[CH2:35][CH2:34][CH2:33]CC4)=[O:26])[CH:20]=3)=[O:13])=[CH:8][CH:9]=2)[CH:4]=[N:3]1.NCCN1CCCCC1>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]([NH:14][C:15]3[CH:16]=[C:17]([CH:36]=[CH:37][CH:38]=3)[O:18][C:19]3[CH:24]=[CH:23][N:22]=[C:21]([C:25]([NH:27][C:28]4[CH:29]=[N:30][CH:35]=[CH:34][CH:33]=4)=[O:26])[CH:20]=3)=[O:13])=[CH:8][CH:9]=2)[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 33944N-(2-Aminoethyl)piperidineHCID 59987525HCID 59987525, compound

Product 1

HCID 59987498HCID 59987498, compound

Procedure

The title compound was prepared in the same manner described for 4-[3-({[(1-methyl-1H-indazol-5-yl)amino]carbonyl}-amino)phenoxy]-N-(2-piperidin-1-ylethyl)pyridine-2-carbox-amide, substituting 3-aminopyridine for 1-(2-aminoethyl)piperidine. 1H-NMR (DMSO-d6) δ 10.39 (s, 1H), 8.93 (s, 1H), 8.72 (s, 1H), 8.63 (d, J=5.4 Hz, 1H), 8.38 to 8.36 (m, 1H), 8.19 (d, J=8.4 Hz, 1H), 7.91 to 7.86 (m, 3H), 7.85 to 7.51 (m, 3H), 7.42 (t, J=2.1 Hz, 1H), 7.52 to 7.17 (m, 4H), 6.85 (dd, J=2.4, 1.5 Hz, 1H), 3.98 (s, 3H); MS LC-MS (M+H)+=480.1, RT=2.81 min.

Sources & evidence

ORD record
ord-e8da86d447c44b07bab7715a741febd1
Source dataset
uspto-grants-2011_12
Patent number
US08076488B2

Reaction notes

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