4-Toluenesulfonyl chloride → HCID 57422343, compound

HRID 658637Notes

Reaction equation

HRID 658637 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1.[CH3:12][C:13]1[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1.[F:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28]Br)=[CH:26][CH:25]=1>>[F:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:1]([CH2:2][C:3]2[CH:4]=[CH:5][C:6]([C:9]([OH:11])=[O:10])=[CH:7][CH:8]=2)[S:19]([C:16]2[CH:17]=[CH:18][C:13]([CH3:12])=[CH:14][CH:15]=2)(=[O:21])=[O:20])=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 73974-Toluenesulfonyl chlorideHCID 655264-(Aminomethyl)Benzoic AcidHCID 680214-Fluorobenzyl bromide

Product 1

HCID 57422343HCID 57422343, compound

Procedure

Prepared as in example 5-11 from 4-(aminomethyl)phenylcarboxylic acid, 4-methylbenzene-1-sulfonylchloride and 4-fluorobenzyl bromide. 1H NMR (400 MHz, DMSO-d6): δ, ppm: 3.11 (s, 3H), 4.21 (s, 2H), 4.24 (s, 2H), 6.94-7.08 (m, 6H), 7.40-7.42 (d, 2H, J=8 Hz), 7.63 (d, 2H, J=8 Hz). 7.73 (d, 2H, J=8 Hz)

Sources & evidence

ORD record
ord-ff1fa4cee0124d6b96e4b147e933e7fd
Source dataset
uspto-grants-2011_12
Patent number
US08076491B2

Reaction notes

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