反应详情

温度

130 °C

A mixture of 5-chloro-2-hydroxy-benzaldehyde (156 g, 1 mol), 2-bromo-butyric acid methyl ester (271 g, 1.5 mol), KI (2 g, 0.012 mol) and K2CO3 (276 g, 2 mol) in DMF (500 mL) was heated at 130° C. for 2 h. After cooled to room temperature, the mixture was concentrated. The residue was partitioned between EtOAc and water. The organic layer was washed with water, brine, dried over anhydrous Na2SO4 and concentrated to give the title compound (240 g).

1. temperatureAfter cooled to room temperature
2. concentrationthe mixture was concentrated
3. customThe residue was partitioned between EtOAc and water
4. washThe organic layer was washed with water, brine
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated