Trifluoroacetic acid → HCID 68777582, compound

HRID 658972Notes

Reaction equation

HRID 658972 reaction equation
[CH3:1][N:2]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]([CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[C:3]1=[O:24].[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>C(Cl)Cl>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[CH3:1][N:2]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:3]1=[O:24]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59585185HCID 59585185, compound

Product 1

HCID 68777582HCID 68777582, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of tert-butyl 4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate from Step B (73 mg, 0.22 mmol) in CH2Cl2 (5 mL) was added trifluoroacetic acid (2 mL). The resulting mixture was stirred at ambient temperature for 1 h then concentrated in vacuo to give the title compound. MS: m/z=233 (M+1).

Workup

  1. concentrationthen concentrated in vacuo

Sources & evidence

ORD record
ord-fcdcacac0a77404c9e8d0fdb85f202a1
Source dataset
uspto-grants-2011_12
Patent number
US08080544B2

Reaction notes

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