3-Amino-1-propanol → HCID 24997347, compound

HRID 659022Notes

Reaction equation

HRID 659022 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=3)=[CH:14][C:13]=2[F:29])=[O:10])=[CH:4][C:3]=1[C:30]([F:33])([F:32])[F:31].[NH2:34][CH2:35][CH2:36][CH2:37][OH:38]>C1COCC1>[F:29][C:13]1[CH:14]=[C:15]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([NH:34][CH2:35][CH2:36][CH2:37][OH:38])[N:20]=2)[CH:16]=[CH:17][C:12]=1[NH:11][C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([C:30]([F:33])([F:32])[F:31])[CH:4]=1)=[O:10]

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 67524074HCID 67524074, compound

Product 1

HCID 24997347HCID 24997347, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 98 mg (0.194 mmol) 1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[2-fluoro-4-(2-methanesulfonyl-pyrimidin-4-yloxy)-phenyl]-urea, 32 mg (0.43 mmol) 3-amino-propan-1-ol and 5 ml THF was stirred at r.t. for 12 h. The reaction mixture was evaporated and the residue purified by chromatography on silica (dichloromethane/ethanol 96:4). Yield 20 mg (21%) of the title compound.

Workup

  1. customThe reaction mixture was evaporated
  2. customthe residue purified by chromatography on silica (dichloromethane/ethanol 96:4)

Sources & evidence

ORD record
ord-d054f5e1e5164c84857bb11ff40d7d18
Source dataset
uspto-grants-2011_12
Patent number
US08080552B2

Reaction notes

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