Triethylamine → HCID 12887440, compound

HRID 659043Notes

Reaction equation

HRID 659043 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].Cl.[CH2:9]([O:11][C:12](=[O:15])CN)[CH3:10].C([N:18](CC)CC)C>CCO>[CH2:9]([O:11][C:12]([NH:18][CH2:3][CH2:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])=[O:15])[CH3:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 8821Ethyl AcrylateHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 12887440HCID 12887440, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl acrylate (a) (50 mL, 460 mmol, 1.1 eq), glycine ethyl ester hydrochloride (b) (58.4 g, 418 mmol, 1 eq), and triethylamine (58.3 mL, 418 mmol, 1 eq) in absolute EtOH (960 mL) was stirred at ambient temperature for approximately 72 h. After reaction was complete, volatile components were removed under vacuum and the crude intermediate (c) was carried on directly.

Workup

  1. customAfter reaction
  2. customvolatile components were removed under vacuum

Sources & evidence

ORD record
ord-b48f192c28864792a7be029fe28c2eb4
Source dataset
uspto-grants-2011_12
Patent number
US08080556B2

Reaction notes

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