Hydroxyamine hydrochloride → HCID 12380594, compound

HRID 65912Notes

Reaction equation

HRID 65912 reaction equation
[CH3:1][N:2]1[C:9](Cl)=[CH:8][C:6](=[O:7])[N:5]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[C:3]1=[O:4].C([O-])(=O)C.[Na+].Cl.[NH2:23][OH:24]>COCCO>[CH3:1][N:2]1[C:9]([NH:23][OH:24])=[CH:8][C:6](=[O:7])[N:5]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[C:3]1=[O:4]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 123805901-Methyl-3-cyclohexyl-6-chlorouracil

Product 1

HCID 12380594HCID 12380594, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A mixture of 7 g of 1-methyl-3-cyclohexyl-6-chlorouracil, 18 g of sodium acetate (trihydrate), 7 g of hydroxylamine hydrochloride and 100 ml of methyl-cellosolve is boiled for 1 hour and, when cold, the insolubles are removed by filtration. The filtrate is concentrated and recrystallized from water-ethanol. By the above procedure is obtained 4 g of 1-methyl-3-cyclohexyl-6-hydroxyaminouracil, melting point: 153°-155° C.

Workup

  1. customwhen cold, the insolubles are removed by filtration
  2. concentrationThe filtrate is concentrated
  3. customrecrystallized from water-ethanol

Sources & evidence

ORD record
ord-0845031587a44710ac33116cdc42dba8
Source dataset
uspto-grants-1978_12
Patent number
US04129654

Reaction notes

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