反应详情

In 50 ml of dimethylformamide is dissolved 1 g of the 7-cyclohexyl-5H,7H-isoxazolo[3,4-d]pyrimidine-4,6-dione obtained in Example 18, followed by addition of 800 mg of potassium carbonate and 1 ml of methyl iodide. The mixture is stirred at room temperature for 20 hours, after which the insolubles are filtered off. The filtrate is concentrated to dryness and the concentrate is dissolved in chloroform. After the insolubles are filtered off, the chloroform is removed by distillation and the residue is recrystallized from water-ethanol. By the above procedure is obtained 0.8 g of the captioned compound as pale-white platelets. melting point: 194°-197° C.

1. filtrationafter which the insolubles are filtered off
2. concentrationThe filtrate is concentrated to dryness
3. dissolutionthe concentrate is dissolved in chloroform
4. filtrationAfter the insolubles are filtered off
5. customthe chloroform is removed by distillation
6. customthe residue is recrystallized from water-ethanol