Tetrahydro-4H-pyran-4-one → HCID 66681522, compound

HRID 659264Notes

Reaction equation

HRID 659264 reaction equation
[NH2:1][CH:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[NH:7][C:8](=[O:23])[C:9]1[C:14]([S:15][CH3:16])=[CH:13][C:12]([C:17]([F:20])([F:19])[F:18])=[CH:11][C:10]=1[O:21][CH3:22].[O:24]1[CH2:29][CH2:28][C:27](=O)[CH2:26][CH2:25]1>>[CH3:22][O:21][C:10]1[CH:11]=[C:12]([C:17]([F:19])([F:20])[F:18])[CH:13]=[C:14]([S:15][CH3:16])[C:9]=1[C:8]([NH:7][CH:3]1[CH2:4][CH2:5][CH2:6][CH:2]1[NH:1][CH:27]1[CH2:28][CH2:29][O:24][CH2:25][CH2:26]1)=[O:23]

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 66681196N-((1RS,2SR)-2-Amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide2×

Product 1

HCID 66681522HCID 66681522, compound

Procedure

The title compound, white solid, MS: m/e=433.2 [(M+H)+], was prepared in accordance with the general method of example 11 from N-((1RS,2SR)-2-amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate O) and tetrahydro-4H-pyran-4-one.

Sources & evidence

ORD record
ord-b27f0c6c23b44f0a8e3c843ba4a3c303
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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