Hydrochloric Acid → HCID 178485117, compound

HRID 65950Notes

Reaction equation

HRID 65950 reaction equation
[C:1]([NH:3][C:4]([NH:16]C)=[N:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[NH:14][CH:13]=[N:12][C:11]=1[CH3:15])#N.[ClH:18]>>[ClH:18].[ClH:18].[CH3:1][NH:3][C:4]([NH2:16])=[N:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[NH:14][CH:13]=[N:12][C:11]=1[CH3:15]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178485005Cimetidine

Product 1

HCID 178485117HCID 178485117, compound

Procedure

A solution of N-cyano-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidine (2.0 g.) in hydrochloric acid (25 ml.) was heated on the steam bath for 2 hours. Concentration followed by recrystallisation of the product from ethanol-ether afforded N-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride (1.44 g.) m.p. 204°-206°.

Workup

  1. concentrationConcentration
  2. customfollowed by recrystallisation of the product from ethanol-ether

Sources & evidence

ORD record
ord-f57a61dc65bf499fb2a6e1048999863f
Source dataset
uspto-grants-1978_12
Patent number
US04129657

Reaction notes

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