反应详情

Thiophene-2-sulfonyl chloride (15 g, 0.082 mol) was dissolved in CHCl3 (200 mL) under N2 atmosphere and then cooled to 0° C. tert-Butylamine (25.9 mL, 0.246 mol) dissolved in CHCl3 (50 mL) was then added dropwise to the reaction mixture. The reaction mixture was stirred for 1 h at room temperature and then at reflux for 10 min. Toluene (700 mL) was added and the organic phase was washed with water (3×50 mL), dried, and concentrated in vacuo. The sub-title product was used without further purification in the next step.

1. additionwas then added dropwise to the reaction mixture
2. temperatureat reflux for 10 min
3. washthe organic phase was washed with water (3×50 mL)
4. customdried
5. concentrationconcentrated in vacuo
6. customThe sub-title product was used without further purification in the next step