2-Fluorophenol → Methyl 5-chloro-2-[(2-fluorophenoxy)methyl]benzoate

HRID 660209Notes

Reaction equation

HRID 660209 reaction equation
BrC[CH2:3][C:4]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7].[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[OH:22]>>[Cl:14][C:11]1[CH:12]=[CH:13][C:4]([CH2:3][O:22][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[F:15])=[C:5]([CH:10]=1)[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 97072-FluorophenolHCID 68983888Methyl 2-(bromoethyl)-5-chlorobenzoate

Product 1

HCID 68862280Methyl 5-chloro-2-[(2-fluorophenoxy)methyl]benzoate

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 1 from methyl 2-(bromoethyl)-5-chlorobenzoate and 2-fluorophenol: 1H-NMR (CDCl3) δ 8.02 (1H, d, J=2.4 Hz), 7.80-7.77 (1H, m), 7.57-7.53 (1H, m), 7.15-6.89 (4H, m), 5.52 (2H, s), 3.92 (3H, s).

Sources & evidence

ORD record
ord-46c92a647ba7413584f6f972bd7951f7
Source dataset
uspto-grants-2011_12
Patent number
US08084476B2

Reaction notes

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