反应详情

温度

0 °C

Ethyl 2-(4-(methoxymethoxy)phenyl)acetate (1.75 g, 7.80 mmol) in DMF (50 mL) was slowly added sodium hydride (330 mg, 8.25 mmol) and iodomethane (1.13 g, 7.96 mmol) at 0° C. The reaction mixture was stirred for 1 hour at 0° C. The mixture was added water (50 mL) and extracted with EtOAc. The organic layer was dried with MgSO4. The organic layer was filtered and the filtrate was concentrated in vacuo. The residue was purified by column chromatography eluting with n-Hexane/EtOAc=15/1.

1. customat 0° C
2. extractionextracted with EtOAc
3. dry with materialThe organic layer was dried with MgSO4
4. filtrationThe organic layer was filtered
5. concentrationthe filtrate was concentrated in vacuo
6. customThe residue was purified by column chromatography
7. washeluting with n-Hexane/EtOAc=15/1