Water → HCID 57742157, compound

HRID 660327Notes

Reaction equation

HRID 660327 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[C:9]([OH:14])[CH:8]=1)[CH3:6])[CH3:2].C1C=CC(O[C:23](Cl)=[S:24])=CC=1.C1CCN2C(=NCCC2)CC1.O>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:15])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]2[NH:13][C:23](=[S:24])[O:14][C:9]=2[CH:8]=1)[CH3:6])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 70498Phenyl thioxochloroformateHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 12370790HCID 12370790, compound

Product 1

HCID 57742157HCID 57742157, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Solution of 2-(4-Amino-3-hydroxy-phenyl)-propionic acid ethyl ester (570 mg) in DMF (5 mL) was added phenyl chlorothionoformate (563 mg in DMF), and DBU (829 mg, in DMF) at room temperature. The reaction mixture was stirred for 14 h at room temperature and water was added to this mixture. The resulting mixture was extracted with ethyl ether. The combined organic layer was dried over magnesium sulfate, filtered and concentrated in vacuo. The resulting residue was chromatographed on silica gel (n-Hex:EtOAc=10:1 to 4:1) to afford the product as yellow oil. (90 mg, 13.2%)

Workup

  1. extractionThe resulting mixture was extracted with ethyl ether
  2. dry with materialThe combined organic layer was dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe resulting residue was chromatographed on silica gel (n-Hex:EtOAc=10:1 to 4:1)

Sources & evidence

ORD record
ord-d54d3a97cb1b48c0bf495a086e72922d
Source dataset
uspto-grants-2011_12
Patent number
US08084484B2

Reaction notes

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