反应详情

To a stirred solution of 6-((S)-2-(((2S,5R)-3,6-diethoxy-5-isopropyl-2,5-dihydropyrazin-2-yl)methyl)-3-methylbutyl)-1-(3-methoxypropyl)-1H-indazole (300 mg, 0.62 mmol) in CH3CN (5 mL) was added 1 N aq HCl (5 mL) at rt. The mixture was stirred for 5 h, poured into ice-cold, satd aq NaHCO3 and extracted with CH2Cl2 (3×20 mL). The combined organic extracts were washed with brine, dried over Na2SO4 and evaporated to give (2S,4S)-ethyl 2-amino-4-((1-(3-methoxypropyl)-1H-indazol-6-yl)methyl)-5-methylhexanoate (220 mg, 95%).

1. extractionextracted with CH2Cl2 (3×20 mL)
2. washThe combined organic extracts were washed with brine
3. dry with materialdried over Na2SO4
4. customevaporated