Hydrochloric Acid → HCID 24969059, compound

HRID 660530Notes

Reaction equation

HRID 660530 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:25][C:24](=[O:26])[NH:23][S:22]3(=[O:28])=[O:27])=[C:17]([OH:29])[CH:16]=2)[CH2:9]1)=O)(C)(C)C.Cl>CCOCC.O1CCOCC1>[OH:29][C:17]1[CH:16]=[C:15]([CH2:14][CH:10]2[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]2)[CH:20]=[CH:19][C:18]=1[N:21]1[S:22](=[O:28])(=[O:27])[NH:23][C:24](=[O:26])[CH2:25]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 24969058HCID 24969058, compound

Product 1

HCID 24969059HCID 24969059, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

To a suspension of 3-[3-hydroxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-piperidine-1-carboxylic acid tert-butyl ester (24 mg, 0.052 mmol) in ether (1.5 mL) is added 2 mL of HCl in dioxane (4 M) and the mixture is stirred at RT for 18 h. The solvent is removed under reduced pressure to give the hydrochloride salt of the title compound: (M−1)−=324.

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-73c626ac225d4422ba1ac779d040c483
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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