HCID 68842585, compound → HCID 57777404, compound

HRID 660604Notes

Reaction equation

HRID 660604 reaction equation
C([O:8][C:9]1[CH:10]=[C:11](/[CH:23]=[CH:24]/[C:25]([NH:27][C:28]([CH3:33])([CH3:32])[C:29]([OH:31])=[O:30])=[O:26])[CH:12]=[CH:13][C:14]=1[N:15]1[CH2:19][C:18](=[O:20])[NH:17][S:16]1(=[O:22])=[O:21])C1C=CC=CC=1>CCOC(C)=O.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH2:23][CH2:24][C:25]([NH:27][C:28]([CH3:33])([CH3:32])[C:29]([OH:31])=[O:30])=[O:26])[CH:12]=[CH:13][C:14]=1[N:15]1[CH2:19][C:18](=[O:20])[NH:17][S:16]1(=[O:22])=[O:21]

Participants

4

Reactant 1

HCID 68842585HCID 68842585, compound

Product 1

HCID 57777404HCID 57777404, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 2{(E)-3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-acryloylamino}-2-methylpropionic acid (40 mg) in EtOAc (4 mL) is hydrogenated at 1 atm over 20 mg of 10% Pd/C for 24 h. The catalyst is filtered through Celite and the solvent removed under reduced pressure to give the title compound as a yellow solid: (M−1)−=384, HPLC retention time=0.71 min. (Method A).

Workup

  1. filtrationThe catalyst is filtered through Celite
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-dfe1928bef4948088dc6098c37c610db
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

Loading…