反应详情

To a solution of 5-tributylstannanyl-2-trimethylsilanylthiazole (4.0 g, 9.0 mmol) in THF is added slowly HCl (1.0N, 3 mL) and the solution is stirred at RT for 1 h. The reaction mixture is extracted with ether, washed with sat. NaHCO31 dried over anhydrous MgSO4 and concentrated to afford the title compound as a yellow oil which is used in the next step without further purification: (M+1)+=375.

1. extractionThe reaction mixture is extracted with ether
2. washwashed with sat. NaHCO31
3. dry with materialdried over anhydrous MgSO4
4. concentrationconcentrated