反应详情

A mixture of (2-benzyloxymethyl-2H-pyrazol-3-yl)-(3-benzyloxy-4-nitrophenyl)-methanol (392 mg, 0.881 mmol), TBSOTf (0.25 mL, 1.09 mmol) and 2,6-lutidine (0.153 mL, 1.32 mmol) in CH2Cl2 is stirred at RT for 2 h. The mixture is partitioned between CH2Cl2 and aqueous NaHCO3. The organic phase is dried over MgSO4 and concentrated. The residue is purified by flash chromatography to give the title compound.

1. customThe mixture is partitioned between CH2Cl2 and aqueous NaHCO3
2. dry with materialThe organic phase is dried over MgSO4
3. concentrationconcentrated
4. customThe residue is purified by flash chromatography