反应详情

A mixture of pyrazole (93 mg, 1.4 mmol), K2CO3 (180 mg, 1.30 mmol) and 2-benzyloxy-4-bromomethyl-1-nitrobenzene (Example 83, step C) (193 mg, 0.599 mmol) in MeCN (5 mL) is stirred at RT for 1 h. Additional pyrazole (500 mg, 7.34 mmol) and K2CO3 (200 mg, 1.45 mmol) are added and the mixture is stirred at RT for an additional 15 h. The mixture is partitioned between EtOAc and water and the organic phase is dried over MgSO4. The solvent is removed under reduced pressure to give the title compound.

1. stirringthe mixture is stirred at RT for an additional 15 h
2. customThe mixture is partitioned between EtOAc and water
3. dry with materialthe organic phase is dried over MgSO4
4. customThe solvent is removed under reduced pressure