Potassium Carbonate → HCID 68842349, compound

HRID 660744Notes

Reaction equation

HRID 660744 reaction equation
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.[CH2:10]([O:17][C:18]1[CH:23]=[C:22]([CH2:24]Br)[CH:21]=[CH:20][C:19]=1[N+:26]([O-:28])=[O:27])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:10]([O:17][C:18]1[CH:23]=[C:22]([CH:21]=[CH:20][C:19]=1[N+:26]([O-:28])=[O:27])[CH2:24][N:5]1[CH:6]=[CH:7][C:3]([C:2]([F:9])([F:8])[F:1])=[N:4]1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 18070343-(Trifluoromethyl)pyrazoleHCID 621150422-Benzyloxy-4-bromomethyl-1-nitrobenzene

Product 1

HCID 68842349HCID 68842349, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 3-trifluoromethyl-1H-pyrazole (632 mg, 4.65 mmol) and 2-benzyloxy-4-bromomethyl-1-nitrobenzene (1.0 g, 3.1 mmol) in DMF (8 mL) is added K2CO3 (642 mg, 4.65 mmol) and the mixture is stirred at RT for 48 h. The mixture is partitioned between EtOAc and water and the organic phase is washed with brine and dried over MgSO4. The solvent is removed under reduced pressure to give the title compound: (M+1)+=378.

Workup

  1. customThe mixture is partitioned between EtOAc and water
  2. washthe organic phase is washed with brine
  3. dry with materialdried over MgSO4
  4. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-ffd8378248104d13945381d994f72e1d
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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