Potassium tert-butoxide → HCID 68838475, compound

HRID 660765Notes

Reaction equation

HRID 660765 reaction equation
[NH2:1][S:2]([N:5]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19](=[O:27])[O:20][CH2:21][CH2:22][Si:23]([CH3:26])([CH3:25])[CH3:24])=[CH:13][C:12]=1[O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:6][C:7](OC)=[O:8])(=[O:4])=[O:3].CC(C)([O-])C.[K+]>C1COCC1>[CH3:24][Si:23]([CH3:26])([CH3:25])[CH2:22][CH2:21][O:20][C:19](=[O:27])[CH2:18][O:17][C:14]1[CH:15]=[CH:16][C:11]([N:5]2[CH2:6][C:7](=[O:8])[NH:1][S:2]2(=[O:4])=[O:3])=[C:12]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:13]=1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 68840538Methyl N-(aminosulfonyl)-N-(2-(benzyloxy)-4-{2-oxo-2-[2-(trimethylsilyl)ethoxy]ethoxy}phenyl)glycinate

Product 1

HCID 68838475HCID 68838475, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of methyl N-(aminosulfonyl)-N-(2-(benzyloxy)-4-{2-oxo-2-[2-(trimethylsilyl)ethoxy]ethoxy}phenyl)glycinate in THF is added potassium t-butoxide (1.1 equivalent) in THF dropwise. The mixture is stirred at RT for 18 h. The solvent is removed under reduced pressure to afford the title compound which is used directly in the next step.

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-0e59aa6acd894632ac7d2a82f4f6c89a
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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