Water → HCID 68839036, compound

HRID 660816Notes

Reaction equation

HRID 660816 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=1[N+:19]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O>CC(O)=O.CCO.[Fe]>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([C:15]([F:16])([F:17])[F:18])[CH:12]=[CH:11][C:10]=1[NH2:19])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 962WaterHCID 15054011HCID 15054011, compound

Product 1

HCID 68839036HCID 68839036, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 18476134Acetic acid ethanolSolvent

Procedure

To a solution of 2-benzyloxy-1-nitro-4-trifluoromethylbenzene (1.0 g. 3.4 mmol) in 16 mL HOAc/EtOH (1:3) is added iron powder and the mixture is refluxed for 2 h. The mixture is cooled to RT and water is added and it is extracted with EtOAc. The organic phase is dried over sodium sulfate and the solvent removed under reduced pressure to give the title compound as a reddish oil.

Workup

  1. temperaturethe mixture is refluxed for 2 h
  2. extractionit is extracted with EtOAc
  3. dry with materialThe organic phase is dried over sodium sulfate
  4. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-9df361a609464c65961546419f36ac73
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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