反应详情

To a vigorously stirred mixture of 4,5-difluoro-2-nitrophenol (1 g, 5.71 mmol) and anhydrous potassium carbonate (1.9 g, 14.28 mmol) in acetone (20 mL). is added benzyl bromide (750 μl, 6.28 mmol) and the dark heterogeneous mixture is heated to reflux for 10 h; or until all starting material had been consumed according to LC/MS analysis. The dark mixture is then filtered, dried over magnesium sulfate, and filtered again to afford, after solvent removal, a light brown crystalline solid that was used in the next step without further purification.

1. temperaturethe dark heterogeneous mixture is heated
2. temperatureto reflux for 10 h
3. customor until all starting material had been consumed
4. filtrationThe dark mixture is then filtered
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered again
7. customto afford
8. customafter solvent removal
9. customa light brown crystalline solid that was used in the next step without further purification