Hydrochloric Acid → HCID 58012134, compound

HRID 660862Notes

Reaction equation

HRID 660862 reaction equation
[CH2:1]([N:3]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([O:12]CC)=[O:11])[N:5]=[C:4]1[C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)[CH3:2].[OH-].[K+].Cl>CO>[CH2:1]([N:3]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([OH:12])=[O:11])[N:5]=[C:4]1[C:15]1[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 58012149HCID 58012149, compound

Product 1

HCID 58012134HCID 58012134, compoundYield 111.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

205 mg (0.67 mmol) of ethyl 4-ethyl-[3-(4-methoxyphenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate from Example 109A are dissolved in 0.46 ml of methanol, treated with 0.18 ml 20% aqueous potassium hydroxide and stirred overnight. Next it is brought to a pH of 1 with 1 N hydrochloric acid, evaporated and the residue dried in vacuo. 207 mg of the target compound is thus obtained as crude product, which is further reacted as such.

Workup

  1. customevaporated
  2. customthe residue dried in vacuo

Sources & evidence

ORD record
ord-5791c636ccea4302a5970d12cb2b361d
Source dataset
uspto-grants-2011_12
Patent number
US08084481B2

Reaction notes

Loading…