Hydrochloric Acid → HCID 68836874, compound

HRID 660892Notes

Reaction equation

HRID 660892 reaction equation
[CH3:1][N:2]([CH3:24])[C:3](=[O:23])[CH:4](NC(=O)OC(C)(C)C)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1.[ClH:25]>O1CCOCC1>[ClH:25].[CH3:24][N:2]([CH3:1])[C:3](=[O:23])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:13])([F:12])[F:14])[CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58012170HCID 58012170, compound

Product 1

HCID 68836874HCID 68836874, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

130 mg (375 μmol) of the compound from Example 174A are stirred at RT in 2 ml of a 4 M solution of hydrogen chloride in dioxan. After complete conversion, the volatile components are removed on the rotary evaporator and the residue dried under high vacuum. 105 mg (99% of theory) of the title compound are obtained.

Workup

  1. customAfter complete conversion, the volatile components are removed on the rotary evaporator
  2. customthe residue dried under high vacuum

Sources & evidence

ORD record
ord-6a5ab579e85447cda0669804a4067e15
Source dataset
uspto-grants-2011_12
Patent number
US08084481B2

Reaction notes

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