Hydrochloric Acid → HCID 58012031, compound

HRID 660942Notes

Reaction equation

HRID 660942 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][CH2:14][CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])[C:11](=[O:23])[N:10]([CH2:24][C:25]([NH:27][CH2:28][C:29]([CH3:41])([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:40])([F:39])[F:38])[CH3:30])=[O:26])[N:9]=2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[C:11](=[O:23])[N:10]([CH2:24][C:25]([NH:27][CH2:28][C:29]([CH3:41])([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:38])([F:39])[F:40])[CH3:30])=[O:26])[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58011795HCID 58011795, compound

Product 1

HCID 58012031HCID 58012031, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound from Example 365 (22 mg, 37 μmol) is stirred overnight at RT with 1 ml of a 4 M hydrogen chloride solution in dioxan. The solvent is then removed on the rotary evaporator. The residue is taken up in DMSO and purified by preparative HPLC (Method 20). 14 mg (70% of theory) of the title compound are obtained.

Workup

  1. customThe solvent is then removed on the rotary evaporator
  2. custompurified by preparative HPLC (Method 20)

Sources & evidence

ORD record
ord-18979c944aec4eedaa5ab673afe99b7d
Source dataset
uspto-grants-2011_12
Patent number
US08084481B2

Reaction notes

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