反应详情

A solution of 5-acetyl-thiophene-2-carboxylic acid (1 g, 5.88 mmol) in DMF (24 mL) is treated with potassium carbonate (813 mg, 5.88 mmol), then iodomethane (0.368 mL, 5.88 mmol), and stirred for 60 h at rt. The reaction mixture is acidified and extracted into ethyl acetate twice. The combined organic layers are washed with brine, dried, filtered, and concentrated, then taken up in ethyl acetate, washed with saturated aqueous potassium carbonate, dried, filtered and concentrated to give 5-acetyl-thiophene-2-carboxylic acid methyl ester (653 mg).

1. extractionextracted into ethyl acetate twice
2. washThe combined organic layers are washed with brine
3. customdried
4. filtrationfiltered
5. concentrationconcentrated
6. washwashed with saturated aqueous potassium carbonate
7. customdried
8. filtrationfiltered
9. concentrationconcentrated