反应详情

0.3 g (0.7 mmol) of the compound from Example 12A, 0.2 g (2.18 mmol) of 3-hydroxyazetidine hydrochloride and 0.2 g (1.4 mmol) of potassium carbonate were initially charged in 6 ml of DMF and reacted in a single-mode microwave (Emrys Optimizer) at 150° C. for 30 min. The crude product was purified by preparative HPLC. Yield: 105 mg (40% of theory)

1. customreacted in a single-mode microwave (Emrys Optimizer) at 150° C. for 30 min
2. customThe crude product was purified by preparative HPLC