反应详情

温度

0 °C

195 mg (0.48 mmol) of 3-(3-ethoxy-1,2,4-oxadiazol-5-yl)-5-[3-fluoro-4-(trifluoromethoxy)phenyl]piperidine were initially charged in 4.5 ml of dichloromethane, cooled to 0° C. and admixed with 0.27 ml (193 mg, 1.91 mmol) of triethylamine and 96 mg (0.48 mmol) of 4-nitrophenyl chloroformate. The reaction mixture was stirred at RT for 1 hour and admixed with water, and the organic phase was removed. The organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 290 mg (94% of theory)

1. customthe organic phase was removed
2. dry with materialThe organic phase was dried over magnesium sulphate
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure