反应详情

温度

0 °C

1.74 g (5.42 mmol) of the compound from Example 92A were initially charged in 80 ml of dichloromethane and cooled to 0° C., and admixed with 1.5 ml (1.09 g, 10.8 mmol) of triethylamine and 1.09 g (5.42 mmol) of 4-nitrophenyl chloroformate. The reaction mixture was allowed to warm up slowly to RT and stirred at RT for 16 h. It was washed repeatedly with water, dried over sodium sulphate, filtered and concentrated under reduced pressure. Yield: 2.4 g (87% of theory)

1. temperatureto warm up slowly to RT
2. washIt was washed repeatedly with water
3. dry with materialdried over sodium sulphate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure