Hydrochloric Acid → HCID 178524590, compound

HRID 66135Notes

Reaction equation

HRID 66135 reaction equation
C([O:3][C:4]([C:6]1[NH:11][C:10]2[CH:12]=[CH:13][C:14](=[O:18])[C:15]([OH:17])=[CH:16][C:9]=2[C:8](=[O:19])[CH:7]=1)=[O:5])C.Cl>>[O:19]=[C:8]1[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[NH:11][C:10]2[CH:12]=[CH:13][C:14](=[O:18])[C:15]([OH:17])=[CH:16][C:9]1=2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178469293HCID 178469293, compound

Product 1

HCID 178524590HCID 178524590, compound

Procedure

A mixture of 4,7-dihydro-4,7-dioxo-6-hydroxy-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (2.5 g, described in Example 3) and 19% hydrochloric acid (75 ml) is refluxed for 1 hour and cooled to room temperature. The crystalline precipitate is collected and washed with water, ethanol and ether to obtain the title compound, mp > 270° C.

Workup

  1. temperatureis refluxed for 1 hour
  2. customThe crystalline precipitate is collected
  3. washwashed with water, ethanol and ether

Sources & evidence

ORD record
ord-78a56da359094e41b40b68c9b96d18ea
Source dataset
uspto-grants-1978_12
Patent number
US04130649

Reaction notes

Loading…