Hydrochloric Acid → HCID 67499729, compound

HRID 661362Notes

Reaction equation

HRID 661362 reaction equation
[Cl-].[Si]([O:9][C:10]1[CH2:11][CH2:12][C:13]2([C:25]([F:28])([F:27])[F:26])[CH:17]([CH:18]=1)[N+:16]([CH3:20])([CH3:19])[C:15]1[CH:21]=[CH:22][CH:23]=[N:24][C:14]2=1)(C(C)(C)C)(C)C.Cl>O1CCCC1>[CH3:19][N:16]([CH3:20])[C:15]1[C:14]([C:13]2([C:25]([F:28])([F:26])[F:27])[CH2:17][CH2:18][C:10](=[O:9])[CH:11]=[CH:12]2)=[N:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67499264HCID 67499264, compound

Product 1

HCID 67499729HCID 67499729, compoundYield 50.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of Example 26A (418 mg, 2.014 mmol) and (E)-3-(tert-butyldimethylsilyloxy)-N,N-dimethylbuta-1,3-dien-1-amine (Aldrich, 527 mg, 2.316 mmol) in toluene (1.5 mL) was heated in a microwave at 140° C. for 2 hours, and then chromatographed on silica gel (AnaLogix SF15-24G; 50 micron silica; elution with 0-50% ethyl acetate in hexane at 20 mL/min). Repeated the reaction in a microwave at 120° C. for 2 hours with a solution of Example 26A (422 mg, 2.033 mmol) and (E)-3-(tert-butyldimethylsilyloxy)-N,N-dimethylbuta-1,3-dien-1-amine (693 mg, 3.05 mmol) in toluene (2 mL), and then chromatographed on silica gel (AnaLogix® SF15-24G; 50 micron silica; elution with 0-50% ethyl acetate in hexane at 20 mL/min). The title compound (165 mg, 0.580 mmol) was isolated as an orange solid. A solution of the isolated intermediate 7-(tert-butyldimethylsilyloxy)-5,5-dimethyl-9a-(trifluoromethyl)-5a,8,9,9a-tetrahydro-5H-pyrido[3,2-b]indol-5-ium chloride (395 mg, 0.908 mmol) in tetrahydrofuran (9 mL) was treated with 1N hydrochloric acid (3.0 mL, 3.0 mmol). The reaction mixture was stirred overnight at ambient temperature, quenched with sodium bicarbonate solution (40 mL), extracted twice with ethyl acetate (40 mL), washed with brine, dried (Na2SO4), and concentrated to an orange oil. The residue was purified by silica gel chromatography (AnaLogix® SF 10-8G; 50 micron silica; elution with 0-40% ethyl acetate in hexane at 15 mL/min) to provide additional title compound (131 mg, 0.461 mmol) as an off-white solid. 1H NMR (300 MHz, CDCl3) δ ppm 8.54 (dd, J=4.5, 1.6, 1H), 7.75 (dd, J=8.0, 1.7, 1H), 7.74 (dd, J=10.2, 2.1, 1H), 7.35 (dd, J=8.1, 4.5, 1H), 5.90 (d, J=10.2, 1H), 3.54-3.44 (m, 1H), 2.65 (s, 3H), 2.45-2.35 (m, 2H), 2.33 (s, 3H), 2.13-1.97 (m, 1H); MS (DCI/NH3) m/e 285 (M+H)+.

Workup

  1. customquenched with sodium bicarbonate solution (40 mL)
  2. extractionextracted twice with ethyl acetate (40 mL)
  3. washwashed with brine
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated to an orange oil
  6. customThe residue was purified by silica gel chromatography (AnaLogix® SF 10-8G; 50 micron silica; elution with 0-40% ethyl acetate in hexane at 15 mL/min)

Sources & evidence

ORD record
ord-1be42741670045c8a31563153badae77
Source dataset
uspto-grants-2011_12
Patent number
US08084616B2

Reaction notes

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